Article 4.1.11.1. Pursuant to Article 67 of Regulation (EC) No 1907/2006, a substance may not be manufactured or used as such, or in a preparation or object to which a restriction in Appendix XVII of Regulation (EC) No 1907/2006 applies, unless the conditions of this restriction are satisfied. This does not apply to the manufacture and use of a substance for scientific research or scientific development. Appendix XVII specifies when the restriction does not apply to research and development carried out on products and processes, and specifies the maximum quantity exempted.